Scientists are looking for the most effective way to tackle diabetes.
A huge number of people risks having inadequate access to life-saving treatment.
Other cells can likely do it too, the researchers believe.
It’s the holy grail of drug delivery.
It’s like a pacemaker for your insulin.
University of Montreal Hospital Research Centre (CRCHUM) scientists have identified a new enzyme that could protect the body from toxic levels of intra-cell sugar. When there is too much sugar in the body it gets processed to glycerol-3-phosphate, a buildup of which can damage internal organs. The team behind the study proved that G3PP is able to extract excess sugar from cells.
Even if it was first discovered more than 90 years ago, insulin is still out of reach for a shocking 29 million diabetes patients in the United States. Yes, this is the 21st century, but even so a staggering number of human beings are forced to live in life threatening conditions. But why is insulin so prohibitively expensive? According to Jeremy Greene, M.D., Ph.D., and Kevin Riggs, M.D., M.P.H., it’s all because of a series of perverse updates to insulin treatments. While insulin made today is more effective in some instances, previous versions weren’t that bad. In fact, they saved lives. Yet, these were replaced with very expensive versions, while the older, much cheaper versions are nowhere to be found on the market anymore. The two authors explore all that’s wrong with today’s insulin big pharma.
What do you do if you need to catch your own food… but you’re just not fast enough? That’s the problem cone snails had to face, and the solution they came up with is pretty amazing: they kill fish by lowering their sugar levels with a unique type of insulin, researchers found
The “one size fits all” approach to diabetics treatment may cause significant problems for older patients also suffering from other conditions. Attempting to aggressively control blood sugar with insulin and sulfonylurea drugs could lead to over-treatment and hypoglycemia (low blood sugar), Yale researchers report.
Drug delivery encapsulated in tiny nanoparticles are thoroughly studied with great interest because they offer the chance to deliver treatments more efficiently. That’s not all though – with nanoparticle pills you can selectively target key areas and deliver drugs which otherwise wouldn’t be possible without using invasive methods. Take diabetes for instance – patients need to take shots of insulin
The reason why some drugs can only be taken by injecting them, instead of less intrusive solutions like oral ingestion, is because otherwise these drugs can not reach the bloodstream effectively. For people suffering from chronic diseases that require a lifetime treatment of drugs administered by injection, like those suffering from diabetes who need an insulin shot every other day,
In what can only be considered a remarkable medical breakthrough, researchers at Universitat Autònoma de Barcelona (UAB) have completely cured type 1 diabetes in dogs after they were injected during a single gene therapy session. The injected gene therapy vectors ensure a healthy expression of glucose, thus the regular insulin shots and associated side effects with the disease are no longer required.
There are a number of factors that lead to obesity, the most obvious of which is of course eating too much, without burning the excess fat by exercising. Fact is, there are some people in the world who no matter how much they’d eat, they never seem to be satisfied, constantly consumed by a sense of hunger and a voracious
Scientists have genetically engineered mice able to express a certain enzyme, which allows for an increased metabolic rate. The lab mice infussed with this enzyme in their fat tissue were able to eat more, but gain far less weight than their naturally bred brethren. It’s generally acknowledged that obesity and inflammation cause insulin resistance, however it’s not perfectly understood why