Quantcast
ZME Science
  • CoronavirusNEW
  • News
  • Environment
    • Climate
    • Animals
    • Renewable Energy
    • Eco tips
    • Environmental Issues
    • Green Living
  • Health
    • Alternative Medicine
    • Anatomy
    • Diseases
    • Genetics
    • Mind & Brain
    • Nutrition
  • Future
  • Space
  • Feature
    • Feature Post
    • Art
    • Great Pics
    • Design
    • Fossil Friday
    • AstroPicture
    • GeoPicture
    • Did you know?
    • Offbeat
  • More
    • About
    • The Team
    • Advertise
    • Contribute
    • Our stance on climate change
    • Privacy Policy
    • Contact
No Result
View All Result
ZME Science

No Result
View All Result
ZME Science
No Result
View All Result
Home Health & Medicine Genetics

Flipping a single “molecular switch” makes an old mouse brain young

Mihai Andrei by Mihai Andrei
March 8, 2013
in Genetics, Mind & Brain
ADVERTISEMENT

A single molecular switch can make the transition between the active, malleable brain of an adolescent and the mature, stable brain of an adult; yep, a single gene can turn us back to the childlike curiosity we exhibit as adolescents.

A neuron cultured for the study. Via Yale University.
A neuron cultured for the study. Via Yale University.

Researchers have known for quite a while that adolescent brains are typically more malleable (or plastic) than adult ones, allowing them  for example to learn foreign languages much faster and recover from any brain injuries. The relative rigidity of the adult brain stems (mostly) from the function of a single gene that slows the rapid change in synaptic connections between neurons. Now, Yale researchers have identified the key genetic switch for brain maturation a study released March 6 in the journal Neuron.

The Nogo Receptor 1 gene supresses the high levels of plasticity in the adolescent brain as you grow up. In mice without this gene, juvenile levels of brain plasticity persist throughout adulthood, allowing them to keep the young, learning-avid brain as they age. Furthermore, the supression of the gene in older mice also reset their brains to the adolescent levels of plasticity.

ADVERTISEMENT

“These are the molecules the brain needs for the transition from adolescence to adulthood,” said Dr. Stephen Strittmatter. Vincent Coates Professor of Neurology, Professor of Neurobiology and senior author of the paper. “It suggests we can turn back the clock in the adult brain and recover from trauma the way kids recover.”

Not only can we recover from trauma the way children do, but we can also literally improve our minds, indirectly keeping the child-like curiosity avid as we age, leading to better and healthier lives. So far, this study has only been conducted on mice, and it will most likely take a while before it is adapted to humans, but I for one am holding my breath. To think that such a big change depends on a single gene…

Get more science news like this...

Join the ZME newsletter for amazing science news, features, and exclusive scoops. More than 40,000 subscribers can't be wrong.

   

“We know a lot about the early development of the brain,” Strittmatter said, “But we know amazingly little about what happens in the brain during late adolescence.”

Tags: brainneuron
Mihai Andrei

Mihai Andrei

Andrei's background is in geophysics, and he's been fascinated by it ever since he was a child. Feeling that there is a gap between scientists and the general audience, he started ZME Science -- and the results are what you see today.

Follow ZME on social media

ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT
  • Coronavirus
  • News
  • Environment
  • Health
  • Future
  • Space
  • Feature
  • More

© 2007-2019 ZME Science - Not exactly rocket science. All Rights Reserved.

No Result
View All Result
  • Coronavirus
  • News
  • Environment
    • Climate
    • Animals
    • Renewable Energy
    • Eco tips
    • Environmental Issues
    • Green Living
  • Health
    • Alternative Medicine
    • Anatomy
    • Diseases
    • Genetics
    • Mind & Brain
    • Nutrition
  • Future
  • Space
  • Feature
    • Feature Post
    • Art
    • Great Pics
    • Design
    • Fossil Friday
    • AstroPicture
    • GeoPicture
    • Did you know?
    • Offbeat
  • More
    • About
    • The Team
    • Advertise
    • Contribute
    • Our stance on climate change
    • Privacy Policy
    • Contact

© 2007-2019 ZME Science - Not exactly rocket science. All Rights Reserved.