homehome Home chatchat Notifications


Genetic mutation explains why some people need to sleep fewer hours

Some lucky people naturally need less sleep than everybody else.

Fermin Koop
September 2, 2019 @ 6:38 pm

share Share

Sleeping the full eight hours usually advised by doctors might not be necessary for everybody, according to a new study, which suggested there’s a gene that dictates how much sleep a person needs.

A researching team at the University of California, headed by Ying-Hui Fu, analyzed the genes of 12 members of a family that sleeps as little as 4.5 hours per night without feeling tired. They found they had a mutation in a gene called ADRB1.

“We all spend about one-third of our lives in the state of sleep,” Fu said. “In fact, considering how important sleep is to our well-being, it’s astonishing that we know so little about how sleep is regulated.”

The team bred rats with the same mutation, which slept about 55 minutes less per day. This correlated with altered activity in a brain region called the dorsal pons that is known to regulate sleep.

In normal rats, ADRB1-expressing brain cells were found to be inactive during most sleep stages, but active when they were awake. In the mutant ones, these cells were even more active during waking hours. The researchers also found they could wake up sleeping rats by artificially activating these ADRB1-expressing brain cells.

The results suggest that ADRB1-expressing brain cells promote wakefulness and that variations in the ADRB1 gene influence how long we can stay awake for each day, said Fu. Her team has previously found that mutations in other genes like DEC2 also make people need to sleep less.

These mutations don’t seem to be associated with any negative health consequences. “Most natural short sleepers are very happy about their sleep pattern – they usually fully take advantage of their extra time,” Fu told New Scientist.

The researchers think the ADRB1 and DEC2 mutations must have emerged recently in human history and haven’t had time to spread widely yet. “The 8-hour norm has been the standard for a long time, but somehow a few new mutations occurred recently and produced this seemingly advantageous trait,” Fud said.

While this is newly discovered mutated gene contributes to short sleep, the study highlighted it’s probably not the only one. There are likely more unrecognized genes and regions of the brain that tell our bodies when to go to bed and rise in the morning.

“Identifying genes, and mutations, that cause people to sleep less naturally without significant negative impact lays the groundwork for scientists to investigate how our sleep homeostasis and efficiency is regulated at the molecular and neuronal levels,” Fu says.

share Share

Researchers Say Humans Are In the Midst of an Evolutionary Shift Like Never Before

Humans are evolving faster through culture than through biology.

Archaeologists Found A Rare 30,000-Year-Old Toolkit That Once Belonged To A Stone Age Hunter

An ancient pouch of stone tools brings us face-to-face with one Gravettian hunter.

Scientists Crack the Secret Behind Jackson Pollock’s Vivid Blue in His Most Famous Drip Painting

Chemistry reveals the true origins of a color that electrified modern art.

China Now Uses 80% Artificial Sand. Here's Why That's A Bigger Deal Than It Sounds

No need to disturb water bodies for sand. We can manufacture it using rocks or mining waste — China is already doing it.

Over 2,250 Environmental Defenders Have Been Killed or Disappeared in the Last 12 Years

The latest tally from Global Witness is a grim ledger. In 2024, at least 146 people were killed or disappeared while defending land, water and forests. That brings the total to at least 2,253 deaths and disappearances since 2012, a steady toll that turns local acts of stewardship into mortal hazards. The organization’s report reads less like […]

After Charlie Kirk’s Murder, Americans Are Asking If Civil Discourse Is Even Possible Anymore

Trying to change someone’s mind can seem futile. But there are approaches to political discourse that still matter, even if they don’t instantly win someone over.

Climate Change May Have Killed More Than 16,000 People in Europe This Summer

Researchers warn that preventable heat-related deaths will continue to rise with continued fossil fuel emissions.

New research shows how Trump uses "strategic victimhood" to justify his politics

How victimhood rhetoric helped Donald Trump justify a sweeping global trade war

Long Before the Egyptians, The World's Oldest Mummies Were Smoked, Not Dried in the Desert

The 14,000-year-old smoked mummies in Southeast Asia are rewriting burial history

Biggest Modern Excavation in Tower of London Unearths the Stories of the Forgotten Inhabitants

As the dig deeper under the Tower of London they are unearthing as much history as stone.