homehome Home chatchat Notifications


High-resolution genome sequence of ancient human ancestor released online

Last year, researchers at the Max Planck Institute for Evolutionary Anthropology, produced a draft of the Denisova genome, in order study in what proportion they relate to homo sapiens sapiens. The  Denisovans, are a new group of hominids, discovered just two years ago, which is believed to have lived around 30,000 years ago, alongside Neanderthals and […]

Tibi Puiu
February 8, 2012 @ 10:27 am

share Share

Last year, researchers at the Max Planck Institute for Evolutionary Anthropology, produced a draft of the Denisova genome, in order study in what proportion they relate to homo sapiens sapiens. The  Denisovans, are a new group of hominids, discovered just two years ago, which is believed to have lived around 30,000 years ago, alongside Neanderthals and early homo sapiens ancestors. Since they first released their draft, the researchers from Germany have now produced a highly refined version of the Denisovan genome, sequenced 30 times, which they also publicaly released on the web to help other scientists with their study.

The idea came after Max Planck paleogeneticist Svante Pääbo was at a meeting in Sweden, and noticed there that his fellow colleagues were working and studying based on year-old sequence data, and that the all the other labs in the world were probably using the same outdated material as well.

“I felt bad knowing that we had this very much better version of the same genome and that it would be a few months before it became available,” says Pääbo.

Even though Pääbo and colleagues have yet to release the paper they’ve been working on for such a long time, the researchers decided to allow their colleagues to download the sequence data for the high-resolution genome today. The sequence can be freely downloaded from  both on Max Planck website and through Amazon’s Web Services. Speaking of which,  this latest version of the genome they’ve released online and which will be presented shortly for scientific publishing, has every position sequenced an average of 30 times – all based on DNA extracted from less than 10 milligrams of the finger bone of the ancient girl found in the Denisovan caves, in Siberia.

Ancestors of homo sapiens breeding

With this higher resolution of the genome in their hands, the scientists can now more accurately determine how our hominid ancestors influenced modern man, since DNA differences can be precisely extracted from that of living humans and Neanderthals. It’s believed that early humans interbred with both Neanderthals and Denisovans. We all currently have Neanderthal genes inside our DNA, however they’re inactive; modern humans in Melanesia and other parts of Asia have inherited about 4% of their DNA from Denisovans.

A third group of extinct humans, Homo floresiensis, nicknamed “the hobbits” because they were so small, also walked the Earth until about 17,000 years ago. It is not known whether modern humans bred with them because the hot, humid climate of the Indonesian island of Flores, where their remains were found, impairs the preservation of DNA.

Of course, to protect their ability to publish a paper, the Max Planck team is releasing the sequence under a license that prohibits anyone else from doing an analysis of the complete genome, nevertheless anyone, scientist or not, is now free to analyze specific genes in the genome without having to wait for the study to pass peer review.

share Share

Some people are just wired to like music more, study shows

Most people enjoy music to some extent. But while some get goosebumps from their favorite song, others don’t really feel that much. A part of that is based on our culture. But according to one study, about half of it is written in our genes. In one of the largest twin studies on musical pleasure […]

In 2013, dolphins in Florida starved. Now, we know why

The culprit is a very familiar one. It's us.

But they're not really dire wolves, are they?

and this isn't a conservation story

Earth Might Run Out of Room for Satellites by 2100 Because of Greenhouse Gases

Satellite highways may break down due to greenhouse gases in the uppermost layers of the atmosphere.

Scientists Found a 380-Million-Year-Old Trick in Velvet Worm Slime That Could Lead To Recyclable Bioplastic

Velvet worm slime could offer a solution to our plastic waste problem.

23andMe Just Filed for Bankruptcy and Your DNA Could Be Up for Grabs

A company once worth billions now faces a reckoning over the fate of your genetic data

World’s Oldest Person Had Cells 17 Years Younger Than Her Age. The Surprising Diet and Habits That Helped Her Live to 117

The supercentenarian’s gut health may hold the key to longevity.

Finally, mRNA vaccines against cancer are starting to become a reality

mRNA vaccines were first developed years ago to target cancers and now they're really starting to show promise.

When Did Humans First Speak? New Genetic Clues Point to 135,000 Years Ago

Language is one of the biggest force multipliers in our species. It appeared earlier than expected.

Scientists Crack Genetic Code for Bigger, Sweeter Tomatoes. The Results Are Delicious

Scientists have unlocked genes that could transform tomatoes, making them both bigger and sweeter.