homehome Home chatchat Notifications


Scientists investigate cannabis terpenes as possible COVID-19 treatment

Aromatic oils that give cannabis its signature taste and smell might have a role to play in fighting the coronavirus.

Tibi Puiu
May 6, 2020 @ 3:19 pm

share Share

Credit: Wikimedia Commons.

Israeli researchers at the forefront of cannabis research are now investigating the potential of a formulation of cannabis terpenes in treating viral infections, COVID-19 included.

Is cannabis effective against COVID-19? Researchers want to know

Secreted in the same glands that produce cannabinoids like THC and CBD, terpenes are aromatic oils that are responsible for the taste and smell of cannabis — but that’s not all that they do.

Research suggests that terpenes play a considerable role in not only tempering the intoxicating effects of THC, but also creating synergy with phytocannabinoids and even increasing their therapeutic value.

In the context of the coronavirus crisis, researchers at the Israel Institute of Technology are testing the therapeutic potential of cannabis terpenes.

During previous severe coronavirus outbreaks, such as those caused by the SARS coronavirus in 2002-2003, researchers found that cannabis terpenes reduced disease severity and impact in both in-vitro and in-vivo. In a 2007 study published in the Journal of Medical Chemistry, Chinese scientists concluded that the terpenes blocked a certain protein that allows the virus to replicate its genetic material.

“Our lab has been approved to operate as a corona lab, and in doing so, we are promoting two studies based on existing cannabis studies,” Professor Dedi Meiri of the Israel Institute of Technology said in a statement for Health Europa.

“First, we will try to identify the plant’s own molecules that are capable of suppressing the immune response to the COVID-19 coronavirus – which causes inflammation and severe disease – to lower the immune system response without suppressing it, thereby providing better complementary treatment to the steroids, which completely suppress the immune system.”

Meiri and colleagues hope that the terpenes might modulate the effect of cytokine storms –– the overreaction of the body’s immune system that can cause complications and multiple organ failure.

The novel formulation is designed to be administered by direct inhalation.

Cytokines are small proteins released by many different cells in the body, including those of the immune system where they coordinate the body’s response against infection and trigger inflammation.

It’s believed that SARS-CoV-2, the virus that causes COVID-19, can trigger cytokine storm syndrome, attacking healthy lungs, eventually causing their collapse.

Besides looking into terpenes’ potential to lower the immune system response, the Israeli researchers are also investigating how these cannabis molecules interact with the ACE2 receptor. It is thanks to this receptor, which is abundantly found in cells in the respiratory tract, that the coronavirus enters cells and begins replicating its genetic material.

“There is a process that examines the effect of cannabis molecules on proteins as well, and we are now examining which ones are relevant to the same receptor, with the goal of reducing its expression, making it difficult for the virus to enter the cell and proliferate,” Meiri said.

Previously, researchers at the University of Lethbridge in Alberta, Canada, found that certain Cannabis sativa extracts could be used in treatments to prevent infection with SARS-CoV-2, the virus that causes COVID-19. 

A word of caution

The results of these preliminary studies shouldn’t by any means be considered an endorsement of cannabis in these trying times. COVID-19 is a severe respiratory illness that is known to aggressively attack the lungs. As such, those who smoke tobacco or marijuana might be at particular risk.

Research on cannabis as a COVID-19 treatment is still ongoing and it will likely take a long time before we have clear answers. In the meantime, don’t self-medicate and risk making matters worse.

share Share

Scientists Just Found the Clearest Evidence Yet That Lucid Dreaming Is a Real State of Consciousness

People who are aware they are dreaming show distinct brain patterns.

Drug Regenerates Retina and Restores Vision in Blind Mice

A protein hidden in our eyes may be the reason we can't repair lost vison.

This Stretchy Battery Still Works After Being Twisted, Punctured, and Cut in Half

Not the most energy dense but its ability to withstand abuse is unparalleled.

The UAE Wants AI to Write Its Laws — What Could Possibly Go Wrong?

But can machines really grasp justice, fairness, and human rights?

Scientists Invent a Color Humans Have Never Seen Before

Meet "olo": a vivid, hyper-saturated blue-green that can't be captured by screens or paint.

This Chewing Gum Can Destroy 95 Percent of Flu and Herpes Viruses

Viruses had enough fun in our mouths, it's time to wipe them out.

Conservative people in the US distrust science way more broadly than previously thought

Even chemistry gets side-eye now. Trust in science is crumbling across America's ideology.

We Could One Day Power a Galactic Civilization with Spinning Black Holes

Could future civilizations plug into the spin of space-time itself?

Scientists filmed wild chimpanzees sharing alcohol-laced fermented fruit for the first time and it looks eerily familiar

New footage suggests our primate cousins may have their own version of happy hour.

China’s Humanoid Robots Stumble, Break Down, and Finish the World’s First Robot Half Marathon

Bipedal bots compete with humans in first half-marathon race — with a bit of help from duct tape.